Research
Does Alzheimer's Start in the Nose? A New Theory on the Disease
Article no. 24 · April 27, 2026 · Updated September 20, 2026 ·

New thoughts and theories on how Alzheimer's might originate
This text has been written with the help of ChatGPT
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1) Sense of Smell Deteriorates Very Early
Many patients experience a deterioration of their sense of smell several years before memory problems.
Studies show that:
- loss of smell can occur 5–10 years before diagnosis
- changes are visible in the olfactory nerve and olfactory bulb.
The structure first affected is often the
Olfactory bulb, located just above the nasal cavity.
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2) Direct Path from Nose to Brain

